Rifampin inhibits the effect of oral contraceptives, quinidine, corticosteroids, warfarin, methadone, digoxin, oral hypoglycemics; aminosalicylic acid may interfere with absorption of rifampin. Significant interactions with protease inhibitors and nonnucleoside reverse transcriptase inhibitors.
Pyrazinamide- Bactericidal to intracellular organisms.
Ethambutol- Bacteriostatic to both intracellular and extracellular organisms. Mainly used to inhibit development of resistant mutants. Use with caution in renal disease or when ophthalmologic testing is not feasible
Optic neuritis (reversible with discontinuance of drug; rare at 15 mg/kg); rash.
Red-green color discrimination and visual acuity (difficult to test in children under 3 years of age).
Streptomycin- Bactericidal to extracellular organisms. Use with caution in older patients or those with renal disease.
Eighth nerve damage, nephrotoxicity.
Vestibular function (audiograms); BUN and creatinine.
Neuromuscular blocking agents may be potentiated and cause prolonged paralysis.