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Monoclonal antibodies approved for Hematological and Solid tumors


ANTIGEN AND TUMOR CELL TARGETS
ANTIGEN FUNCTION
NAKED ANTIBODIES
Antigen: CD20
Proliferation/differentiation
Rituximab (chimeric)
Tumor type: B-cell lymphoma and CLL
Antigen: CD52
Unknown
Alemtuzumab (humanized)
Tumor type: B-cell CLL and T-cell lymphoma
Antigen: CD25 alpha subunit
Activation antigen
Daclizumab (humanized)
Tumor type: T-cell mycosis fungoides
Antigen: CD33
Unknown
Gemtuzumab (humanized)
Tumor type: acute myeloid leukemia
Antigen: HER2/neu (ErbB-2)
Tyrosine kinase
Trastuzumab (humanized)
Tumor type: breast cancer
Antigen: EGFR (ErbB-1)
Tyrosine kinase
Cetuximab (chimeric)
Tumor type: colorectal; NSCLC; pancreatic, breast
Antigen: VEGF
Angiogenesis
Bevacizumab (humanized)
Tumor type: colorectal cancer

1 comment:

  1. Thanks for this, so helpful information. Anyway, have a visit in this link www.creative-biolabs.com you will found some related studies. :)

    ReplyDelete

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