| Sign | Upper motor neurone | Lower motor neurone |
| 1) Weakness | Voluntary movements are disturbed | Paralysis of muscles supplied by that segment or nerve |
| 2) Tone | Hypertonia (clasp- knife spasticity | Hypotonia |
| 3) Reflex ( tendon) | Increased,+- clonus | Decreased or absent |
| 4) Reflex ( superficial) | Absent or decreased | Absent or decreased |
| 5) Plantar response | Extensor | Flexor or absent |
| 6) Muscle nutrition | Disuse atrophy | Marked atrophy |
| 7) Fasciculations | Absent | Present |
| 8) Reaction of degeneration | Absent | Present |
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