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Drugs that May Reduce Combined Hormonal Contraceptive Efficacy




Interacting Drug

Documentation

Antituberculous
 

  Rifampin

Established; reduced efficacy if 50 microg EE

Antifungals
 

  Griseofulvin

Strongly suspected

Anticonvulsants and sedatives
 

  Phenytoin, mephenytoin, phenobarbital, primidone, carbamzepine, ethosuximide

Strongly suspected; reduced efficacy if 50 microg EE; trials lacking

Antibiotics
 

  Tetracycline, doxycycline

Two small studies find no association

  Penicillins

No association documented

  Ciprofloxacin

No effect on efficacy of a 30 microg EE + desogestrel pill

  Ofloxacin

No effect on efficacy of a 30 microg EE + levonorgestrel pill

Antiretrovirals

Variable effects; see manufacturer or other


EE = ethinyl estradiol.

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