SEARCH (Type the topic here)

Vasopressin Receptors


*The cellular effects of vasopressin (ADH) are mediated mainly by interactions of the hormone with the three types of receptors, V1a, V1b, and V2.

*The V1a receptor is the most widespread subtype of Vasopressin receptor; it is found in vascular smooth muscle, the adrenal gland, myometrium, the bladder, adipocytes, hepatocytes, platelets, renal medullary interstitial cells, vasa recta in the renal microcirculation, epithelial cells in the renal cortical collecting-duct, spleen, testis, and many CNS structures.

*V1b receptors have a more limited distribution and are found in the anterior pituitary, several brain regions, the pancreas, and the adrenal medulla.

*V2 receptors are located predominantly in principal cells of the renal collecting-duct system but also are present on epithelial cells in the thick ascending limb and on vascular endothelial cells.

*Although originally defined by pharmacological criteria, vasopressin receptors now are defined by their primary amino acid sequences.

*The cloned vasopressin receptors are typical heptahelical G protein–coupled receptors.

*Manning and coworkers (1999) have synthesized novel hypotensive vasopressin peptide agonists that do not interact with V1a, V1b, or V2 receptors and may stimulate a putative vasopressin vasodilatory receptor. Finally, two additional putative receptors for vasopressin have been cloned.

*A vasopressin-activated Ca2+-mobilizing receptor with one transmembrane domain binds vasopressin and increases intracellular Ca2+. A dual angiotensin II–vasopressin heptahelical receptor activates adenylyl cyclase in response to both angiotensin II and vasopressin. The physiological roles of these putative vasopressin receptors are unclear.

2 comments:

  1. My husband was diagnosed with early onset Parkinson's disease at 57.his symptoms were shuffling of feet,slurred speech, low volume speech, degradation of hand writing, horrible driving skills, right arm held at 45 degree angle, things were tough for me, but now he finally free from the disease with the help of total cure ultimate health home, he now walks properly and all symptoms has reversed, he had trouble with balance especially at night, getting into the shower and exiting it is difficult,getting into bed is also another thing he finds impossible.we had to find a better solution for his condition which has really helped him a lot,the biggest helped we had was ultimatehealthhome they walked us through the proper steps,am highly recommended this ultimatehealthhome@gmail.com to anyone who needs help.

    ReplyDelete

  2. i was diagnosed of parkinson disease 5 years ago,i started azilect then mirapex as the disease progressed in frebuary last year,and i started on parkinson disease herbal treatment from Ultimate Life Clinic,few months into the treatment i made a significant recovery,almost all my symptoms are gone,great improvement with my movement and belance,it been a year and life has been so good for me,contact them through there website www.ultimatelifeclinic.com

    ReplyDelete

Related Posts Plugin for WordPress, Blogger...
Related Posts Plugin for WordPress, Blogger...