Characterstic Drug Toxicities

Agranulocytosis


· Clozapine

Aplastic Anemia


· Chloramphenicol
· NSAIDs
· Benzene

Atropine-like Side Effects


· Tricyclics

Cardiotoxicity


· Doxorubicin
· Daunorubicin

Cartilage Damage in children


· Fluoroquinolones (Ciprofloxacin & Norfloxacin)

Cinchonism


· Quinidine

Coronary Steal Phenomenon


· Dipyridamole

Corneal micro deposits


· Amiodarone

Cough


· ACE Inhibitors

Diabetes Insipidus


· Lithium

Disulfiram-like effect


· Metronidazole
· Sulfonylureas (1st generation)

Extrapyramidal Side Effects


· Antipsychotics (Thioridazine, Haloperidol, Chlorpromazine)

Fanconi’s Syndrome


· Tetracycline

Fatal Hepatotoxicity (necrosis)


· Valproic Acid
· Halothane
· Acetaminophen

Gingival Hyperplasia


· Phenytoin

Gray Baby Syndrome


· Chloramphenicol

Gynecomastia


· Cimetidine
· Azoles
· Spironolactone
· Digitalis
· Estrogen & testosterone
· INH & ethionamide
· Clomiphine
· Phenytoin
· Reserpine & Methyldopa

Hand Foot Syndrome


· 5-Flurouracil (5-FU)

Hemolytic Anemia in G6PD-deficiency


· Sulfonamides
· Isoniazid
· Aspirin
· Ibuprofen
· Primaquine

Hemorrhagic Cystitis


· Cyclophosphamide
· Ifosamide (Treat by Mesna & Acetylcysteine Bladder Wash)

Hepatitis


· Isoniazid

Hot Flashes, Flushing


· Niacin
· Tamoxifen
· Ca++ Channel Blockers

Hypertension: Postural


· Prazocin

Hypertension: Rebound


· Clonidine withdrawal

Increased intra cranial tension (­ ICT)


· Amiodarone
· Hypervitaminosis A
· OCP’s
· Tetracycline
· Quinolones

Induce CP450


· Barbiturates
· Phenytoin
· Carbamazepine
· Rifampin

Inhibit CP450


· Cimetidine
· Erythromycin
· Ketoconazole
· Isoniazid (INH) [remember CEKI]

Interstitial Nephritis


· Methicillin
· NSAIDs (except Aspirin)
· Furosemide
· Sulfonamides

Milk Alkali Syndrome


· Calcium Carbonate (CaCo3)

Monday Disease


· Nitroglycerin Industrial exposure ® tolerance during week ® loss of tolerance during weekend ® headache, tach, dizziness upon re-exposure

Nephrotoxicity


· Cephaloridine
· Gentamycin
· Amphotericin

Orange Body Fluids


· Rifampin

Osteoporosis


· Heparin
· Corticosteroids

Pancreatitis


· L-Asparginase
· Glucocorticoids

Photosensitivity


· Lomefloxacin
· Pefloxacin

Positive Coombs’ Test


· Methyldopa

Pulmonary Fibrosis


· Bleomycin
· Amiodarone

Rabbit Syndrome (Perioral tremors)


· Phenothiazines

Red Man Syndrome


· Vancomycin (rapid IV)

Severe HTN with Tyramine


· MAOIs

SLE- Drug Induced
[Anti Histone Antibody Characteristic of this]


· Chloropromazine
· Hydralazine
· Isoniazid
· Methyldopa
· Procainamide
· Quinidine [ remember CHIMP -Q]

Tardive Dyskinesia


· Antipsychotics (Thioridazine, Haloperidol, Chlorpromazine)

Tinnitus


· Aspirin
· Quinidine

Torsades de Pontis


· Terfanadine